THE BEST SIDE OF CONOLIDINE ALKALOID FOR CHRONIC PAIN

Most recently, it's been recognized that conolidine and the above mentioned derivatives act within the atypical chemokine receptor three (ACKR3. Expressed in equivalent parts as classical opioid receptors, it binds into a wide array of endogenous opioids. As opposed to most opioid receptors, this receptor acts like a scavenger and will not activate